Influence of Rauwiloid(R), Alkaloidal Extract of Rauwolfia serpentine, on Veratrum-Induced Emesis in Dogs.
- 1 May 1955
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 89 (1) , 57-59
- https://doi.org/10.3181/00379727-89-21715
Abstract
Rauwiloid, a selected alkaloidal extract of Rauwolfia serpentina, given orally for 5 days to dogs at a dose of 0.5 mg/kg/day, significantly elevated the emetic threshold to intravenously administered Veriloid in those animals which were sedated. No alteration in the emetic threshold was observed in non-sedated animals. Pre-medication of dogs with intravenously administered phenobarbital sodium at a dose of 25 mg/kg which produced a degree of sedation apparently similar to that of Rauwiloid, was without effect on emesis induced by Veriloid.Keywords
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