Targeting Lymphatic Metastasis
- 7 June 2002
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 296 (5574) , 1811-1812
- https://doi.org/10.1126/science.10731318
Abstract
Oncologists have long debated the part played by the lymphatic system of cancer patients in tumor metastasis. In a Perspective, Gershenwald and Fidler discuss new findings ( Padera et al.) showing that the lymphatic vessels surrounding tumors contribute to lymphatic metastasis. The authors propose that one therapeutic approach to preventing lymphatic metastasis is to block VEGF-C, a lymphangiogenic factor.Keywords
This publication has 9 references indexed in Scilit:
- Lymphatic Metastasis in the Absence of Functional Intratumor LymphaticsScience, 2002
- Molecular mechanisms of lymphangiogenesis in health and diseaseCancer Cell, 2002
- Lymphatic dissemination of tumour cells and the formation of micrometastasesThe Lancet Oncology, 2002
- A model for gene therapy of human hereditary lymphedemaProceedings of the National Academy of Sciences, 2001
- Lymphatic Vessels as Targets of Tumor Therapy?The Journal of Experimental Medicine, 2001
- VEGF-D promotes the metastatic spread of tumor cells via the lymphaticsNature Medicine, 2001
- Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3Nature Medicine, 2001
- Multi-Institutional Melanoma Lymphatic Mapping Experience: The Prognostic Value of Sentinel Lymph Node Status in 612 Stage I or II Melanoma PatientsJournal of Clinical Oncology, 1999
- Lymphatic metastasisCancer and Metastasis Reviews, 1983