Immunity-Related Genes and Gene Families in Anopheles gambiae
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- 4 October 2002
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 298 (5591) , 159-165
- https://doi.org/10.1126/science.1077136
Abstract
We have identified 242 Anopheles gambiae genes from 18 gene families implicated in innate immunity and have detected marked diversification relative to Drosophila melanogaster. Immune-related gene families involved in recognition, signal modulation, and effector systems show a marked deficit of orthologs and excessive gene expansions, possibly reflecting selection pressures from different pathogens encountered in these insects' very different life-styles. In contrast, the multifunctional Toll signal transduction pathway is substantially conserved, presumably because of counterselection for developmental stability. Representative expression profiles confirm that sequence diversification is accompanied by specific responses to different immune challenges. Alternative RNA splicing may also contribute to expansion of the immune repertoire.Keywords
This publication has 40 references indexed in Scilit:
- Comparative Genome and Proteome Analysis of Anopheles gambiae and Drosophila melanogasterScience, 2002
- Requirement for a Peptidoglycan Recognition Protein (PGRP) in Relish Activation and Antibacterial Immune Responses in DrosophilaScience, 2002
- Innate Immune RecognitionAnnual Review of Immunology, 2002
- Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coliNature, 2002
- The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition proteinNature, 2002
- Drosophila innate immunity: an evolutionary perspectiveNature Immunology, 2002
- Innate immune defense against malaria infection in the mosquitoCurrent Opinion in Immunology, 2001
- A family of peptidoglycan recognition proteins in the fruit flyDrosophila melanogasterProceedings of the National Academy of Sciences, 2000
- Molecular interactions between Anopheles stephensi midgut cells and Plasmodium berghei: the time bomb theory of ookinete invasion of mosquitoesThe EMBO Journal, 2000
- Genetic Selection of a Plasmodium -Refractory Strain of the Malaria Vector Anopheles gambiaeScience, 1986