Isolation of STLV–I from Orangutan, a Great Ape Species in Southeast Asia, and Its Relation to Other HTLV–Is/STLV–Is
- 1 January 1997
- journal article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 88 (1) , 1-4
- https://doi.org/10.1111/j.1349-7006.1997.tb00293.x
Abstract
To study the evolutionary origin of human T–lymphotropic virus type I/simian T–lymphotropic virus type I (HTLV–I/STLV–I), we isolated and characterized STLV–I from orangutans (Pongo pygmaeus). Plasma samples from 3 out of 41 animals examined were reactive by particle agglutination and immunofluorescence, and one of these three was confirmed to be anti–HTLV–I antibody–positive by western blotting (WB). Cultured peripheral blood mononuclear cells from the WB–positive orangutan were reactive to anti–STLV–I–positive rhesus monkey plasma. The proviral long terminal repeat region was amplified by polymerase chain reaction and sequenced. A phylogenetic analysis indicated that orangutan STLV–I is related to the Melanesian group of HTLV–Is and other Asian STLV–Is, but the degree of divergence is considerable.Keywords
This publication has 26 references indexed in Scilit:
- HTLV Type I Isolated from a Pygmy in Cameroon Is Related to but Distinct from the Known Central African TypeAIDS Research and Human Retroviruses, 1995
- HTL V-I from Iranian Mashhadi Jews in Israel is phylogenetically related to that of Japan, India, and South America rather than to that of Africa and MelanesiaVirus Genes, 1995
- Phylogenetic subtypes of human T-lymphotropic virus type I and their relations to the anthropological background.Proceedings of the National Academy of Sciences, 1994
- Genetic Analysis and Molecular Phylogeny of Simian T-Cell Lymphotropic Virus Type I: Evidence for Independent Virus Evolution in Asia and AfricaVirology, 1994
- LTR sequence and phylogenetic analyses of a newly discovered variant of HTLV-I isolated from the Hagahai of Papua New GuineaVirology, 1992
- Nucleotide Sequence Analysis of Isolates of Human T-Lymphotropic Virus Type 1 of Diverse Geographical OriginsAIDS Research and Human Retroviruses, 1991
- Highly divergent molecular variants of human T-lymphotropic virus type I from isolated populations in Papua New Guinea and the Solomon Islands.Proceedings of the National Academy of Sciences, 1991
- Sequence homoiogy of the simian retrovirus genome with human t-cell leukemia virus type IVirology, 1985
- Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.Proceedings of the National Academy of Sciences, 1983
- Estimation of average number of nucleotide substitutions when the rate of substitution varies with nucleotideJournal of Molecular Evolution, 1982