LEUKOCYTE INTERFERON (IFN-ALPHA) IN PATIENTS WITH EPITHELIAL OVARIAN-CARCINOMA

  • 1 January 1983
    • journal article
    • research article
    • Vol. 2  (2) , 133-138
Abstract
Human leukocyte interferon (IFN.alpha.) was administered to 15 patients with epithelial ovarian carcinoma after previous chemotherapy or therapeutic irradiation. One objective response was observed. Three patients had possible stable disease for up to 6 mo., including 2 patients who were re-explored 6 mo. after commencing IFN.alpha. and 1 patient who was observed to have a > 50% reduction in her tumor diameters. Three of 7 patients demonstrated clinical responses to subsequent chemotherapy, indicating an absence of resistance to subsequent chemotherapy. Toxicity included the relatively mild symptoms of anorexia, lassitude and diarrhea. Malabsorption was observed in 1 patient. Platelet depression and abnormal enzyme liver functions were also observed more frequently following IFN.alpha.. No life-threatening toxicity was observed.

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