Molecular cloning and functional characterization of human lymphotactin.
Open Access
- 1 July 1995
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 155 (1) , 203-209
- https://doi.org/10.4049/jimmunol.155.1.203
Abstract
We describe the isolation of a cDNA that encodes human lymphotactin (Ltn), a new class of lymphocyte-specific chemokine. Human Ltn shows similarity to some members of the C-C chemokine family but has lost the first and third cysteine residues that are characteristic of the C-C and C-X-C chemokines. Ltn is chemotactic for lymphocytes but not for monocytes, a characteristic that makes it unique among chemokines. In addition, calcium flux desensitization studies indicate that Ltn uses a unique receptor. The human Ltn gene maps to a different chromosome than do the C-C and C-X-C chemokine families. Taken together, these characteristics indicate that Ltn is the first example of a new class of human chemokines with preferential effects on lymphocytes.This publication has 11 references indexed in Scilit:
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