QUINIDINE-INDUCED EXFOLIATIVE DERMATITIS

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Abstract
Although quinidine is a useful drug in the treatment of cardiac arrhythmia, it has long been known that its use is fraught with a variety of hazards. The serious mishaps most frequently encountered in quinidine therapy are the results of overexertion of its therapeutic effects on the hearts that are being treated with it (for example, the occurrence of cardiac standstill during the changeover from a cardiac arrhythmia to a normal rhythm). Such types of quinidine toxicity are, of course, not true drug idiosyncrasies but are untoward effects that are predictable on the basis of the known pharmacologic actions of the drug. They have been thoroughly discussed by Gold in his recent monograph.1 The commoner and milder manifestations of cinchonism, such as dizziness, tinnitus, impaired hearing, blurred vision and tremor, are well known to users of quinidine, as are the symptoms of gastrointestinal irritation. It is our purpose to

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