Biocatalytic reduction of ketones by a semi-continuous flow process using supercritical carbon dioxide
- 22 April 2003
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 10,p. 1198-1199
- https://doi.org/10.1039/b301452e
Abstract
The immobilized resting-cell of Geotrichum candidum was used as a catalyst for the reduction of a ketone in a semi-continuous flow process using supercritical carbon dioxide for the first time; it was also applied for the asymmetric reduction of a ketone and resulted in excellent enantioselectivity (ee >99%) and a higher space-time yield than that of the corresponding batch process.Keywords
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