Evidence that the coproporphyrinogen oxidase activity of rat liver is situated in the intermembrane space of mitochondria

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Abstract
Preferential rupture of the outer membrane of mitochondria from rat liver releases coproporphyrinogen oxidase [EC 1.3.3.3] in parallel with components of the intermembrane space. Coproporphyrinogen III enters the mitochondrion through the freely-permeable outer membrane. Either protoporphyrinogen IX or protoporphyrin IX must then cross the inner membrane before heme synthesis can be completed.