Marine actinomycete diversity and natural product discovery
Top Cited Papers
- 1 January 2005
- journal article
- review article
- Published by Springer Nature in Antonie van Leeuwenhoek
- Vol. 87 (1) , 43-48
- https://doi.org/10.1007/s10482-004-6540-1
Abstract
Microbial natural products remain an important resource for drug discovery yet the microorganisms inhabiting the world’s oceans have largely been overlooked in this regard. The recent discovery of novel secondary metabolites from taxonomically unique populations of marine actinomycetes suggests that these bacteria add an important new dimension to microbial natural product research. Continued efforts to characterize marine actinomycete diversity and how adaptations to the marine environment affect secondary metabolite production will create a better understanding of the potential utility of these bacteria as a source of useful products for biotechnology.Keywords
This publication has 14 references indexed in Scilit:
- Tapping into microbial diversityNature Reviews Microbiology, 2004
- Marine natural productsNatural Product Reports, 2004
- Statistical Approaches for Estimating Actinobacterial Diversity in Marine SedimentsApplied and Environmental Microbiology, 2003
- Natural Products as Sources of New Drugs over the Period 1981−2002Journal of Natural Products, 2003
- Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus SalinosporaAngewandte Chemie International Edition in English, 2003
- Widespread and Persistent Populations of a Major New Marine Actinomycete Taxon in Ocean SedimentsApplied and Environmental Microbiology, 2002
- Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)Nature, 2002
- Lomaiviticins A and B, Potent Antitumor Antibiotics from Micromonospora lomaivitiensisJournal of the American Chemical Society, 2001
- Comparative sequence analyses reveal frequent occurrence of short segments containing an abnormally high number of non-random base variations in bacterial rRNA genesMicrobiology, 2000
- ACTINOMYCETES IN MARINE SEDIMENTSPublished by Elsevier ,1984