A High-Yielding Synthesis of 3-Cyanophthalides
- 1 March 1986
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 16 (4) , 425-430
- https://doi.org/10.1080/00397918608057718
Abstract
Dehydration, with dicyclohexylcarbodiimide. of the cyanohydrins derived from the ring open tautomers of the 3-hydroxyphthalides (4) provides an efficient synthesis of 3-cyanophthalides° (8a) and its derivatives (8b-f).Keywords
This publication has 17 references indexed in Scilit:
- A facile total synthesis of racemic aklavinonetTetrahedron, 1984
- A convergent synthesis of (+)-4-demethoxydaunomycinone and ( + )-daunomycinoneTetrahedron, 1984
- Phthalide annulation: the synthesis of kalafungin, pachybasin and chrysophanolThe Journal of Organic Chemistry, 1983
- An exceptional 5-endo–trig reversal; a convergent synthesis of daunomycinoneCanadian Journal of Chemistry, 1983
- Facile regio- and stereoselective total synthesis of racemic aklavinoneJournal of the American Chemical Society, 1981
- Total syntheses of (.+-.)-duanomycinone. Regiospecific preparations of (.+-.)-7,9-dideoxydaunomycinone and 6,11-dihydroxy-4-methoxy-7,8,9,10-tetrahydronaphthacene-5,9,12-trioneJournal of the American Chemical Society, 1981
- A novel methoxy-directed ketal hydrolysis and its application to a convergent, regiospecific synthesis of (.+-.)-daunomycinoneJournal of the American Chemical Society, 1981
- The regiospecific preparation of 1,4-dioxygenated anthraquinones: a new route to islandicin, digitopurpone, and madeirinJournal of the Chemical Society, Chemical Communications, 1981
- New synthetic methods for the regioselective annelation of aromatic rings: 1-hydroxy-2,3-disubstituted naphthalenes and 1,4-dihydroxy-2,3-disubstituted naphthalenesThe Journal of Organic Chemistry, 1978
- New synthetic strategy for the preparation of linear phenolic natural productsJournal of the American Chemical Society, 1977