Role of Akt Signaling in Vascular Homeostasis and Angiogenesis
Top Cited Papers
- 28 June 2002
- journal article
- review article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 90 (12) , 1243-1250
- https://doi.org/10.1161/01.res.0000022200.71892.9f
Abstract
Akt is a serine/threonine protein kinase that is activated by a number of growth factors and cytokines in a phosphatidylinositol-3 kinase–dependent manner. Although antiapoptotic activity of Akt is well known, it also regulates other aspects of cellular functions, including migration, glucose metabolism, and protein synthesis. In this review, Akt signaling in endothelial cells and its critical roles in the regulation of vascular homeostasis and angiogenesis will be discussed.Keywords
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