Use of NN′-isopropylidene dipeptides in peptide synthesis
- 1 January 1977
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 17,p. 1954-1960
- https://doi.org/10.1039/p19770001954
Abstract
The direct condensation of dipeptides with acetone has been found generally useful for the preparation of 2-(2,2,4-trialkyl-5-oxoimidazolidin-1-yl)alkanoic acids. Peptide synthesis using these NN′-isopropylidene dipeptides may be conveniently carried out with dicyclohexylcarbodi-imide; such couplings are racemisation-free even in the absence of additives. Subsequent deprotection may be effected by hydrolysis under neutral conditions. If required. NN′-isopropylidene dipeptides may be stabilised temporarily towards hydrolysis by conversion into their N-benzyloxycarbonyl or N-nitroso-derivatives.This publication has 1 reference indexed in Scilit:
- Inactivation of oxytocin by acetone.Proceedings of the National Academy of Sciences, 1965