ON THE ACTION OF HORMONES WHICH ACCELERATE THE RATE OF OXYGEN CONSUMPTION AND FATTY ACID RELEASE IN RAT ADIPOSE TISSUE IN VITRO

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Abstract
Hormones capable of accelerating the release of fatty acids from adipose tissue also stimulate the oxygen consumption of this tissue in vitro. Hormones which possess this dual action include epinephrine, adrenocorticotropin, glucagon, thyrotropin, certain growth hormone preparations, the urinary fat mobilizing substance of Chalmers et al., and the 2 pituitary peptides separated by Astwood and coworkers. Some of these compounds show a species specificity in their dual action. It is suggested that the stimulation of oxygen consumption is secondary to the liberation of fatty acids by these hormones and is a reflection of an increased consumption of high-energy phosphate for the re-esterification of these fatty acids.