Comparative pharmacokinetics of cefoperazone and cefamandole
Open Access
- 1 February 1981
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 19 (2) , 298-301
- https://doi.org/10.1128/aac.19.2.298
Abstract
The pharmacokinetics of cefoperazone, a new beta-lactam antibiotic, were studied in normal volunteers and compared with the pharmacokinetics of cefamandole. After a 30-min infusion of 2 g of cefoperazone, the mean serum level was 256 micrograms/ml; at 4 h, the serum level was 20 micrograms/ml, and at 24 h, the level was 1.25 micrograms/ml, compared with levels of cefamandole of 188 micrograms/ml at the end of infusion, 1.8 micrograms/ml at 4 h, and none detected thereafter. The mean half-life of cefoperazone was 1.6 h, compared with 0.7 h for cefamandole. The area under the curve was 356 micrograms/ml per h for cefoperazone, which was three times that for cefamandole. The apparent volume of distribution for cefoperazone was 9.9 liters/1.73 m2 compared with 12.5 liters/1.73 m2 for cefamandole. Serum clearance of cefoperazone was 85 ml/min, and renal clearance was 25 ml/min, compared with a serum clearance of 224 ml/min and a renal clearance of 213 ml/min for cefamandole. Urine levels exceeded 25 micrograms/ml in the first 8 h after injection. Renal recovery of cefoperazone was only 29%.This publication has 5 references indexed in Scilit:
- Cefoperazone: absorption, excretion, distribution, and metabolism.1980
- Single-dose pharmacokinetics of cefoperazone following intravenous administration.1980
- Comparative pharmacokinetics of cefoperazone and cefotaxime.1980
- Comparative Activity and β-Lactamase Stability of Cefoperazone, a Piperazine CephalosporinAntimicrobial Agents and Chemotherapy, 1979
- Assessment of Pharmacokinetic Constants from Postinfusion Blood Curves Obtained after I.V. InfusionJournal of Pharmaceutical Sciences, 1970