Synthesis and biological activity of glycosylated analogs of the C‐terminal hexapeptide and heptapeptide of Substance P
- 1 March 1983
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 21 (3) , 254-257
- https://doi.org/10.1111/j.1399-3011.1983.tb03102.x
Abstract
The synthesis of two glycosylated analogs of Substance P is described. The activity of the peptides was assayed on the isolated guinea-pig ileum and their degradation was studied using rat hypothalamus slices. While glycosylation noticeably enhances the solubility of the corresponding compounds, the β-glucopyranosyl moiety only slightly modifies the biological half-life and the bioactivity of the glycopeptides.Keywords
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