SPECIFICITY AND Ig CLASS OF PREFORMED ALLOANTIBODIES CAUSING A POSITIVE CROSSMATCH IN RENAL TRANSPLANTATION
- 1 August 1993
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 56 (2) , 298-303
- https://doi.org/10.1097/00007890-199308000-00008
Abstract
Sixty-five kidney transplantations performed across a noncurrent alloantibody-positive T cell crossmatch or an alloantibody-positive B cell crossmatch were studied retrospectively. The DTT crossmatch was used to discriminate between IgM and IgG donor-reactive antibodies. Subsequently the HLA specificity of donor-reactive IgG antibodies was determined in the MAILA assay. The first transplantations performed across a noncurrent positive T cell DTT crossmatch (IgG) were associated with poor graft survival, as only 5 of 11 (45%) transplants were functioning at 1 year. The HLA specificity of donor T cell reactive IgG antibodies appeared to determine the fate of the graft: only 2 of 7 (29%) patients with donor HLA class I-reactive antibodies had functioning grafts at 1 year, whereas all 3 patients with donor T cell-reactive antibodies, lacking HLA specificity, had functioning grafts. In 17 first transplantations, 15 grafts (88%) transplanted across an IgM-positive B cell cross match wereKeywords
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