DETECTION OF THYMOSIN-5 IN CALF AND MOUSE THYMUS AND IN NUDE-MOUSE DYSGENETIC THYMUS

  • 1 January 1979
    • journal article
    • review article
    • Vol. 25  (1) , 49-55
Abstract
Thymosin 5 was traced in calf and mouse thymuses by fluorochrome-labeled rabbit anti-calf thymosin. The presence of thymosin 5 or its individual components was found in the following: in groups of cortical epithelial cells in calf thymuses and in single cortical epithelial cells in mouse thymuses, in some marginal (blastema) cells of the thymus cortex of calves and 14 day old mice, in perivascular epithelial cells of the calf thymus, and in occasional medullary epithelial cells of the calf and mouse thymus. In all cases there was a marked alternation of entirely negative and positive cell-containing thymic lobuli. In 4 of 13 cases, comparatively strong positivity was found in tightly arranged epithelial cells in an individual acinus in the dysgenetic thymus of nude mice, the positive cases being concentrated among the youngest mice studied.