IMMUNOLOGICAL RELATION OF BASEMENT MEMBRANE AND A SERUM BETA GLOBULIN IN THE MOUSE. DEMONSTRATION OF RENAL BASEMENT MEMBRANE ALTERATION IN MICE INJECTED WITH STREPTOLYSIN S.

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  • 1 July 1963
    • journal article
    • Vol. 6  (4) , 331-44
Abstract
Antiserum to a fraction of mouse β globulin isolated by electrophoresis and column chromatography was found reactive by immunofluorescence with renal basement membrane of glomeruli and tubules, and with basement membrane and connective tissue in other organs. This method for staining renal basement membrane was applied to the study of renal lesions produced in mice by streptolysin S. In lesions characterized by early changes of acute tubular necrosis a marked decrease in ability to stain tubular basement membrane was observed. Reappearance of staining property in basement membrane was linked to re-regeneration of diseased tubules. Repeated injections of streptolysin S produced alterations in staining also of glomerular basement membrane