Studies on peptides. CVI. Synthesis of a physalaemin-like peptide,(Lys5,Thr6)-physalaemin,isolated from the skin of a frog,Uperoleia rugosa.
- 1 January 1982
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 30 (1) , 344-348
- https://doi.org/10.1248/cpb.30.344
Abstract
An undecapeptide amide, H-Pyr-Ala-Asp-Pro-Lys-Thr-Phe-Tyr-Gly-Leu-Met- NH2, corresponding to the entire amino acid sequence of an amphibian [vasoactive] peptide, [Lys5, Thr6]-physalaemin was synthesized using the thioanisole-mediated trifluoromethane-sulfonic acid deprotection procedure. The synthetic peptide was as active as the natural peptide, in terms of the contractility in guinea pig ileum, and its potency relative to that of synthetic substance P was 0.467.This publication has 0 references indexed in Scilit: