Flow Injection Chemiluminescence Determination of Etamsylate with Electrogenerated Hypochlorite

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Abstract
A fast and simple electrogenerated unstable reagent chemiluminescence system for flow injection analysis of etamsylate is described, based on a decrease in the chemiluminescence intensity from the luminol-hypochlorite system. The response is linear to the concentration of etamsylate in the range from 1x109 to 8x 10−9. The detection limit is 6 x 10−10 g ml−1. The relative standard deviation is 3.1% at 2 x 10−9 g ml−1 (n=7). The proposed method is suitable for automatic and continuous analysis and has been successfully tested for determination of etamsylate in pharmaceutical formulations.