Malignant Extra-adrenal Phaeochromocytoma

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Abstract
Three cases of malignant phaeochromocytoma (paraganglioma) are described. Two of them were metas-tasizing, the third was widely infiltrating and therefore inoperable. All 3 tumors were extra-adrenal, 2 were pharmacologically inactive, one (the inoperable case) had typical clinical signs of pheochromocytoma such as attacks of hypertension and increased excretion of urinary catecholamines. All 3 patients were given radiotherapy, 2 of them post-operatively and one as the only treatment. The response to irradiation was fairly poor. One of the patients died, 2 are alive 3 and 2 years after therapy. Attention is drawn to the protective amines excreted by pharmacologically active pheochromocytomas as one of the reasons for the poor response to radiotherapy.

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