EFFECT OF INTRA-DUODENAL LOAD OF ENDOGENOUS ACID ON SECRETIN RELEASE IN PATIENTS WITH PEPTIC-ULCER

  • 1 January 1982
    • journal article
    • research article
    • Vol. 77  (7) , 471-476
Abstract
In order to explore secretory mechanisms in peptic ulcer, the plasma secretin response to an intraduodenal load of gastric acid stimulated with tetragastrin was studied in 10 patients with duodenal ulcer, 9 with gastric ulcer and 5 young healthy volunteers. After the injection of tetragastrin, plasma secretin level was significantly increased in all subjects. The integrated incremental secretin output significantly correlated with the incremental acid output in the duodenal ulcer group, as well as the gastric ulcer group. There was no significant difference in the integrated incremental secretin output among the 3 groups. The integrated incremental secretin output per unit amount of gastric acid loaded in the duodenum was significantly lower in the duodenal ulcer group than in the other 2 groups. In patients with duodenal ulcer, the secretin release in response to an intraduodenal load of endogenous acid, probably impaired.