Nonrandom distribution of chromosome breaks in cultured lymphocytes of normal subjects
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 31 (2) , 161-175
- https://doi.org/10.1007/bf00296144
Abstract
Breakpoint distribution was studied from cultured lymphocytes on 7653 metaphases from 524 subjects whose karyotypes were normal. The mean break rate was 5% in both sexes. The frequency increased significantly after 40 years and varied during the year. The location of the breaks was very different from the expected random distribution. The break frequency for each chromosome was different according to the type of break (chromatid, simple chromosomal and chromosomal involving rearrangements). The location of the breaks was also studied according to the type of band and with respect to the centromere. A comparison between spontaneous breaks, X-ray induced breaks, breaks in Fanconi's anemia and in congenital rearrangements, show very significant differences.Keywords
This publication has 11 references indexed in Scilit:
- An Analysis of the Break Points of Structural Rearrangements in ManJournal of Medical Genetics, 1974
- The internal order of the interphase nucleusPublished by Springer Nature ,1974
- The sites of radiation induced-breakage in human lymphocyte chromosomes, determined by quinacrine fluorescenceMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1973
- High resolution studies on the pattern of induced exchanges in the human karyotypeChromosoma, 1973
- Nonrandom distribution of chromosome breaks in Fanconi’s anemiaCytogenetic and Genome Research, 1973
- Radiation-induced non-random chromosome breakageExperimental Cell Research, 1972
- Inter- and intrachromosomal distribution of achromatic lesions and chromatid breaks in human chromosomesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1972
- VIRUSES AND CHROMOSOMAL ABNORMALITIESAnnals of the New York Academy of Sciences, 1970
- Cytogenetical Polymorphism and Evolution in Mammalian Somatic Cell Populations in vivo and in vitroNature, 1968
- Age and ChromosomesNature, 1966