Protein Kinases in the Regulation of Apoptosis in B-cell Chronic Lymphocytic Leukemia
- 1 January 2003
- journal article
- review article
- Published by Taylor & Francis in Leukemia & Lymphoma
- Vol. 44 (11) , 1865-1870
- https://doi.org/10.1080/1042819031000110964
Abstract
The involvement of several protein kinase pathways in the regulation of apoptosis and cell survival has been analyzed in a wide range of models. This article reviews current understanding of the protein kinases involved in the control of apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells. Protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3K) and nuclear factor-kappa B (NF-κB) play important roles in the survival of these leukemic cells. These survival pathways affect proteins involved in the control of apoptosis by altering their expression or function. The elucidation of the signal transduction network involved in the survival of B-CLL cells could provide novel pharmacological targets for the therapy of B-CLL.Keywords
This publication has 47 references indexed in Scilit:
- Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cellsBlood, 2003
- Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-κB/Rel–regulated inhibitors of apoptosisBlood, 2002
- Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase CδBlood, 2002
- Live or let die: the cell's response to p53Nature Reviews Cancer, 2002
- A novel treatment approach for low grade lymphoproliferative disorders using PKC412 (CGP41251), an inhibitor of protein kinase CThe Hematology Journal, 2002
- NF-κB at the crossroads of life and deathNature Immunology, 2002
- Survival of leukemic B cells promoted by engagement of the antigen receptorBlood, 2001
- STAT signaling in the pathogenesis and treatment of leukemiasOncogene, 2000
- The cAMP Signaling Pathway as a Therapeutic Target in Lymphoid MalignanciesLeukemia & Lymphoma, 2000
- Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase AktScience, 1997