Unnatural Nucleosides with Unusual Base Pairing Properties
- 1 July 2001
- journal article
- review article
- Published by Wiley in Current Protocols in Nucleic Acid Chemistry
- Vol. 5 (1) , 1.4.1-1.4.13
- https://doi.org/10.1002/0471142700.nc0104s05
Abstract
Synthetic modified nucleosides designed to pair in unusual ways with natural nucleobases have many potential applications in nucleic acid biochemistry. This overview lays the foundation for future protocol units on synthesis and application of unnatural bases, with particular emphasis on unnatural base analogs that mimic natural bases in size, shape, and biochemical processing. Topics covered including base pairs with alternative H‐bonding schemes, hydrophobic base pairs, degenerate bases, universal nucleosides, and triplex constituents.Keywords
This publication has 68 references indexed in Scilit:
- Conformations of Nucleoside Analogue 1-(2‘-Deoxy-β-d-ribofuranosyl)-1,2,4-triazole-3-carboxamide in Different DNA Sequence ContextsBiochemistry, 2001
- Efforts toward Expansion of the Genetic Alphabet: DNA Polymerase Recognition of a Highly Stable, Self-Pairing Hydrophobic BaseJournal of the American Chemical Society, 1999
- Replication of non-hydrogen bonded bases by DNA polymerases: A mechanism for steric matchingBiopolymers, 1998
- Difluorotoluene, a Nonpolar Isostere for Thymine, Codes Specifically and Efficiently for Adenine in DNA ReplicationJournal of the American Chemical Society, 1997
- Oligonucleotides Containing 2-Aminoadenine and 2-Thiothymine Act as Selectively Binding Complementary AgentsBiochemistry, 1996
- Design and Synthesis of Heterocyclic Carboxamides as Natural Nucleic Acid Base MimicsNucleosides and Nucleotides, 1996
- Synthesis, Structure, and Deoxyribonucleic Acid Sequencing with a Universal Nucleoside: 1-(2'-Deoxy-.beta.-D-ribofuranosyl)-3-nitropyrroleJournal of the American Chemical Society, 1995
- Nonstandard Hydrogen Bonding in Duplex Oligonucleotides. The Base Pair between an Acceptor-Donor-Donor Pyrimidine Analog and a Donor-Acceptor-Acceptor Purine AnalogJournal of the American Chemical Society, 1994
- Enzymic recognition of the base pair between isocytidine and isoguanosineBiochemistry, 1993
- Synthesis and thermal stability of dodecadeoxyribonucleotides containing deoxyinosine pairing with four major bases.CHEMICAL & PHARMACEUTICAL BULLETIN, 1989