Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation.
Open Access
- 1 August 1993
- journal article
- review article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 90 (15) , 6900-6903
- https://doi.org/10.1073/pnas.90.15.6900
Abstract
Human immunodeficiency virus variation is extensive and is based on numerous mistakes in reverse transcription. All retrovirus replication requires two strand transfers (growing point jumps) to synthesize the complete provirus. I propose that the numerous mistakes in reverse transcription are the result of this requirement for the two strand transfers needed to form the provirus.Keywords
This publication has 21 references indexed in Scilit:
- Molecular MatchmakersScience, 1993
- Rate and Mechanism of Nonhomologous Recombination During a Single Cycle of Retroviral ReplicationScience, 1993
- Mechanism of DNA Strand Transfer Reactions Catalyzed by HIV-1 Reverse TranscriptaseScience, 1992
- Mechanism of Transduction by RetrovirusesScience, 1992
- Sex and recombination in retrovirusesTrends in Genetics, 1991
- HIV mutation rateNature, 1990
- Rapid development of isolate-specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous seraAIDS, 1990
- Fidelity of HIV-1 Reverse TranscriptaseScience, 1988
- Ordered Interstrand and Intrastrand DNA Transfer During Reverse TranscriptionScience, 1988
- Structure, Replication, and Recombination of Retrovirus Genomes: Some Unifying HypothesesJournal of General Virology, 1979