Distribution of bovine fetuin and albumin in plasma, allantoic and amniotic fluids during development

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Abstract
A radioimmunoassay for bovine fetuin was developed and its specificity and validity established. Albumin was measured by radial-immunodiffusion assay. Fetuin levels in fetal plasma increased from 10 to 15 mg/ml between 4-8 mo. of gestation; albumin levels remained higher than fetuin. Neonatal plasma fetuin levels rapidly declined during the first 14 days postpartum, coincident with a marked reciprocal increase in albumin levels. In allantoic fluid fetuin and albumin concentrations reached a peak at 7 mo. but fetuin values were always higher. In amniotic fluid both proteins peaked at 8 mo.; albumin levels were similar to those in allantoic fluid but fetuin values remained consistently lower than those in allantoic fluid throughout gestation. Fetuin levels in maternal plasma declined from 0.7 to 0.4 mg/ml between 1 mo. and term. At term there is an abrupt change from fetuin synthesis to increased albumin synthesis by the neonatal liver. Fetuin appears to be preferentially accumulated in the allantois; albumin is equally concentrated in the allantois and amnion.

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