Primary chemotherapy with cyclophosphamide, methotrexate, and 5‐fluorouracil in operable breast carcinoma

Publisher Website
Google Scholar
Abstract
BACKGROUND: Primary chemotherapy (PC) is becoming an accepted practice to treat large tumors to avoid mastectomies and as a surrogate of outcome.METHODS: A series of 305 patients with tumors > 3 cm with T2–3N0–1M0 classification were treated with a multimodal approach that consisted of 3 courses of primary cyclophosphamide, methotrexate, and 5‐fluorouracil (CMF) followed by appropriate local treatment and 3 more courses of CMF or 4 courses of doxorubicin. Response was assessed by mammography.RESULTS: The overall response rate was 48% (a 3% pathologic complete response rate). Conservative surgery was achieved in 79.64% of the patients with a low rate of local disease recurrences (5%). Toxicity was minimal. With a median follow‐up of 104 months, the 8‐year disease‐free survival (DFS) rate was 57.63% and the 8‐year overall survival (OS) was 67.65%. The DFS and OS rates for patients with a clinical response were significantly longer, i.e., 70% (P = 0.0048) and 90% (P = 0.0042), respectively.CONCLUSIONS: PC with CMF was feasible. A high rate of breast‐conservative surgery was achieved. The current results stressed the value of PC to increase conservative surgery and as a predictor of outcome. Cancer 2005. © 2005 American Cancer Society.

This publication has 26 references indexed in Scilit: