RELATIONSHIPS BETWEEN PSYCHOLOGICAL MEASUREMENTS AND CEREBRAL ORGANIC-CHANGES IN ALZHEIMERS-DISEASE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 7  (1) , 45-49
Abstract
Twenty-two patients were carefully defined as having progressive dementia without other known cause and not complicated by clinical or laboratory evidence of multi-infarct dementia. Their degree of dementia measured by the ESD [Extended Scale for Dementia] correlated highly with EEG disturbance (r = -0.79). The LPRS [London Psychogeriatric Rating Scale] correlated 0.73 with ventricular enlargement. Although the EEG and CT [computed tomography] scan only correlated significantly with each other in advanced cases, a combined index of EEG and CT Scan change (Physical Measures Index) achieved a correlation of 0.93 with a combined index of psychological change (Psychological Measures Index). The possibility of using physical and psychological measures to monitor quantitative change in Alzheimer''s Disease was indicated, with the EEG contributing more initially and the CT scan more in the most advanced cases.

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