Myelin lipophilin-induced demyelinating disease of the central nervous system
- 1 October 1980
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 5 (10) , 1137-1145
- https://doi.org/10.1007/bf00966171
Abstract
Purified lipophilin, a hydrophobic lipoprotein of myelin, induces a cell-mediated demyelinating disease of the central nervous system similar to experimental allergic encephalomyelitis (EAE) induced by the myelin basic protein (MBP). Guinea pigs challenged with lipophilin (emulsified with CFA) developed clinical and histological signs of disease indistinguishable from those developed by animals similarly challenged with MBP. Both lipophilin and MBP induced and elicited delayed-type hypersensitivity in animals challenged with respective antigens. Tryptophan, an essential component of the MBP-determinant for disease in guinea pigs, is required for the encephalitogenicity of lipophilin.This publication has 19 references indexed in Scilit:
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