OCCURRENCE OF THYROID NODULES IN CHILDREN FOLLOWING THERAPY WITH RADIOIODINE FOR HYPERTHYROIDISM*

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Abstract
Between May 1945 and July 1953, 213 patients with toxic diffuse goiter were treated with I131 at the University of California Hospital, San Francisco. Five to ten years following therapy, thyroid nodules appeared in 3 of the 18 patients less than 20 years old. Two of these children with late nodules were among the 5 treated before the age of 10 years. The evidence suggests that these nodules are true neoplasms. One showed invasion through its capsule and was classified as an invasive adenoma or low-grade carcinoma. Among the 195 radioiodine-treated patients who were over 20 years of age, there were 2 in whom thyroid nodules were palpable at four and six months after euthyroidism had been attained. In these 2 patients the nodules were found at twelve and fifteen months, respectively, after the initial treatment with radioiodine. In no adult was a nodule first discovered at a later time.

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