Histopathologic evaluation of the effects of four calcium hydroxide liners on monkey pulps

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Abstract
Pulpal response of 4 calcium hydroxide liners, MPC 10 [Multi-Placement Compounds with pH of 10], MPC 12 [Multi-Placement Compounds with pH of 12], Dycal and Pulpdent were tested on primary and permanent teeth with zinc oxide and eugenol (ZOE) and silicate as controls. Responses of the pulps were evaluated in Rhesus monkeys, utilizing Class V cavity preparations at 3 days, 5 and 8 wk. An equivalent number of anterior and posterior teeth were studied for all compounds. The Ca(OH)2 liners, ZOE and silicate controls were placed in 80 primary and 80 permanent teeth. Following perfusions the teeth were prepared utilizing routine histological procedures. The 3 day response of the calcium hydroxides was moderate with some disruption in the odontoblasts, vacuolization and mild inflammation underlying the cavity except Pulpdent which was more severe. At 5 wk a decrease in inflammatory response and the formation of reparative dentin was similar for all calcium hydroxides tested at this time period. At 8 wk more reparative dentin was noted with slight to moderate pulpal responses. At all time periods ZOE produced the least pulpal response while silicate produced the most severe response at 5 and 8 wk.

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