Effectiveness of Latrodectus Tredecimguttatus Antivenin in Protecting Laboratory Mice Against Effects of Intraperitoneal Injections of Latrodectus Mactans Venom
- 1 July 1955
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 4 (4) , 762-764
- https://doi.org/10.4269/ajtmh.1955.4.762
Abstract
Summary Latrodectus tredecimguttatus antivenin produced in Yugoslavia proved effective in protecting 20-gram white mice from lethal doses of venoms of L. mactans and L. hasseltii. In all potency tests intraperitoneal injections of venom were followed in 30 minutes by intraperitoneal injections of antivenin. Test animals were observed for a 24 hour period, after which time results were recorded. Death and survival were regarded as endpoints. Amounts of venom were expressed as portions of the contents of one venom gland. One-fourth the contents of one venom gland constituted the minimum certain lethal dose of L. mactans venom for white mice. Complete protection against effects of two certain lethal doses of mactans venom was afforded by amounts of antivenin as low as 0.1 cc. of a 1:1 dilution.Keywords
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