THERMAL COAGULATION OF SERUM IN DIAGNOSIS
- 6 May 1950
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 143 (1) , 11-15
- https://doi.org/10.1001/jama.1950.02910360013005
Abstract
The coagulation of protein by heat has long been accepted as a useful diagnostic aid in the recognition of albumin and Bence Jones proteins in the urine. During some studies of cancer in man several new methods were devised whereby certain abnormalities of the proteins in the blood may be recognized by thermal coagulation; these changes are hypoalbuminemia, abnormal serum albumin and considerable increases of gamma globulin. The changes are not characteristic of cancer, although one or more of them is often associated with malignant disease. Abnormal tests of thermal coagulation of serum signify a disturbed bodily state; they indicate disease but do not reveal its specific nature. The methods are attractive from the standpoints of simplicity and reproducibility, and we have found them useful in diagnosis and prognosis. According to Mirsky and Pauling,1native protein molecules are maintained in a folded configuration by hydrogen bonds. When an aqueousKeywords
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