Host Defense Failure: The Role of Phagocyte Dysfunction

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Abstract
The prototype of bactericidal dysfunction syndromes is chronic granulomatous disease; recent research has made it clear that the classic form is but one of many inherited disorders in which phagocytosis proceeds normally but cells cannot kill the ingested bacteria. In some patients with recurrent infections and normal immunoglobulins, assays of cellular bactericidal capability may open the way to effective therapy.

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