Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2′-deoxyuridylate and 5,10-methylenetetrahydrofolate
- 1 August 1990
- journal article
- research article
- Published by Elsevier in Journal of Molecular Biology
- Vol. 214 (4) , 937-948
- https://doi.org/10.1016/0022-2836(90)90347-o
Abstract
No abstract availableThis publication has 38 references indexed in Scilit:
- Crystallographic refinement by simulated annealingJournal of Molecular Biology, 1988
- The hybridization state of nitrogen as a conformational variable in biologically active moleculesJournal of the Chemical Society, Perkin Transactions 2, 1988
- Relationship between 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthase activity subsequent to 5-fluorouracil administration, in xenografts of human colon adenocarcinomasBiochemical Pharmacology, 1986
- Functional Role of Aspartic Acid-27 in Dihydrofolate Reductase Revealed by MutagenesisScience, 1986
- On the importance of orientation in general base catalysis by carboxylateBioorganic Chemistry, 1981
- On the Mechanism of Action of Folate-And Biopterin-Requiring EnzymesAnnual Review of Biochemistry, 1980
- Effects of polyoxyanions on sulfhydryl group modification of thymidylate synthetaseBiochemistry, 1978
- Über Pterinchemie. 69 Mitteilung [1]. Konformationsanalyse von 5,6,7,8‐Tetrahydropteroinsäure und 5,6,7,8‐Tetrahydro‐L‐folsäureHelvetica Chimica Acta, 1978
- Elucidation of the detailed structures of the native and denatured ternary complexes of thymidylate synthetase via fluorine-19 NMRJournal of the American Chemical Society, 1978
- Thymidylate synthetase: Fluorine-19 nmr characterization of the active site peptide covalently bound to 5-fluoro-2′-deoxyuridylate and 5,10-methylenetetrahydrofolateBiochemical and Biophysical Research Communications, 1976