CIRCULATING IMMUNE-COMPLEXES IN SERUM FROM PATIENTS WITH DENGUE HEMORRHAGIC-FEVER

  • 1 January 1979
    • journal article
    • research article
    • Vol. 36  (1) , 46-53
Abstract
Circulating immune complexes were detectable in 80% of serum from patients with dengue hemorrhagic fever. The immune complexes were first detected on day 2 after the onset of the fever. The amount of complexes reached the maximum value on day 4 or 5 after onset or when the patients developed shock or subsidence of fever, after which the complexes decreased in number. The number of complexes correlated well with the clinical grading (severity) of the disease, i.e., the maximum amount was shown in grade III. These complexes may play a part in the pathogenesis of this disease.