Co‐ordinated regulation of muscle glycolysis and hepatic glucose output in exercise by catecholamines acting via α‐receptors

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Abstract
Recent findings indicate that glucose uptake by contracting hindlimb [Acta Physiol. Scand. (1982) 116, 215‐222] and heart [Biochem. Biophys. Res. Commun. (1982) 108, 124–131] of the rat is stimulated by epinephrine acting through α‐adrenergic mechanisms. Since in exercise hepatic glucose output may be increased markedly by activation of α‐adrenergic receptors and matched by the increase in muscle glucose uptake (maintaining blood glucose levels relatively constant), it is now proposed that a general coordination of glucose metabolism may operate via α‐adrenergic receptor mechanisms. The basis for this proposal is discussed.