Biochemical properties of acetylcholine receptor subunits from Torpedo californica

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Abstract
Polypeptide chains (4) composing acetylcholine receptors from the electric organ of T. californica were purified by preparative electrophoresis in sodium dodecyl sulfate. Their apparent mole ratio .alpha./.beta./.gamma./.delta. is 2:1:1:1. These chains are not readily distinguished by amino acid or carbohydrate composition but are distinguished by apparent MW and polypeptide maps. By peptide maps, no extensive homology is evident between these chains or between any of these chains and higher MW chains found in receptor-enriched membrane fragments.