Biological Activities of Novel Zaragozic Acids, the Potent Inhibitors of Squalene Synthase, Produced by the Fungus, Mollisia sp. SANK 10294.
Open Access
- 1 January 1997
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 50 (5) , 390-394
- https://doi.org/10.7164/antibiotics.50.390
Abstract
Four novel zaragozic acids, F-10863 A, B, C and D, were isolated from a culture broth of the fungus Mollisia sp. SANK 10294. F-10863 compounds contain a 4, 6, 7-trihydroxy-2, 8-dioxyobicyclo[3.2.1]octane-3, 4, 5-tricarboxylic acid core like previously reported zaragozic acids, but the structures of the side chains are different. Recently, it was found that F-10863 A is identical to zaragozic acid D3, while the other three are novel compounds. F-10863 compounds are potent inhibitors of squalene synthase like previously reported zaragozic acids, and, furthermore, they exhibit serum cholesterol-lowering activity in vivo.Keywords
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