Naive T cells can mediate delayed‐type hypersensitivity response in T cell receptor transgenic mice
- 1 July 1994
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 24 (7) , 1512-1516
- https://doi.org/10.1002/eji.1830240708
Abstract
We produced transgenic mice expressing Tcell receptor-αβ chain genes, derived from the chicken ovalbumin (OVA)-specific I-Ad-restricted CD4+CD8− T helper cell clone 7–3–7. In transgenic mice with H-2d genetic background (Tg-d mice), delayed-type hypersensitivity (DTH) was induced in the hind footpad by one inoculation with OVA without any previous sensitization, suggesting that naive T cells have the potential to be involved in DTH response. Spleen cells from nonimmunized Tg-d mice showed a strong T cell proliferative response to in vitro stimulation with OVA. Furthermore, these spleen cells produce cytokines including interleukin(IL)-2, IL-3, interferon-γ, granulocyte/macrophage colony-stimulating factor, macrophage inflammatory protein (MIP)-1α and MIP-1β, which may play an important role in the attraction of mononuclear cells to an antigen-challenging site.Keywords
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