Effect of fluoride administration on plasma fluoride and food intake in the rat

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Abstract
The effect of the continuous intravenous infusion of 2-6 mg fluoride/day on food intake and tissue fluoride concentrations was investigated. A direct association between food intake and plasma fluoride concentration was found. Increasing the amount of fluoride infused per day, or extending the duration of infusion at a constant rate, resulted in an increase of plasma fluoride concentrations to a maximum of 5.5 ppm and a decrease in voluntary food intakes. It was also demonstrated that when fluoride is ingested in the diet, there is a marked diurnal variation in plasma fluoride concentrations. Dietary fluoride levels which were high enough to cause a reduction in food intake caused a significant increase in plasma fluoride, whereas lower levels of fluoride in the diet did not.

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