INFLUENCE OF DELAYED RESORPTION ON SPECIFIC GONADOTROPIC AUGMENTATION

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Abstract
The so-called specific augmentation of prolan by FSH was altered by the delayed resorption of either component and was relatively less if the prolan was more resorbed and relatively more if the FSH was more slowly resorbed. An increment of FSH superimposed upon prolan had the same order of influence (augmentation) it would have if superimposed on itself under conditions of delayed resorption. The so-called specific augmentation might be considered a response in which the "antagonism" phenomenon, readily produced when pituitary extracts were rapidly resorbed, was not elicited. The response to prolan as measured by ovarian wt. increase was increased by delayed resorption but to a lesser degree than that manifested by the pituitary hormone. The mare serum hormone response was not appreciably affected.

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