The effect of immobilization and exercise on acetylcholine‐mediated myopathies

Publisher Website
Google Scholar
Abstract
Experimental myopathies have been produced in the rat both by inhibition of cholinesterase (paraoxon) and by enhancing the release of acetylcholine (guanidine). In the present experiment, the effect of immobilization and exercise on the development of these myopathies was studied. Immobilization, which increases phasic innervation patterns, was found to protect against the myopathy. In contrast, in the contralateral limb, which had assumed greater tonic function, the muscles were more severely affected. Exercise had no effect on the severity or frequency of muscle lesions. It was concluded that tonic innervation patterns make the muscle more vulnerable to these myopathies, providing further evidence for the hypothesis that the myopathies are neurally mediated.

This publication has 0 references indexed in Scilit: