Curative Potencies against α-Amanitin Poisoning by Cytochrome c
- 1 September 1972
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 177 (4051) , 808-809
- https://doi.org/10.1126/science.177.4051.808
Abstract
The fatalities occurring after ingestion of the poisonous mushroom Amanita phalloides are thought to be due to α-amanitin. Cytochrome c provided antidotal effects against a lethal dose of this toxin in mice. Significant survival was obtained even when the treatment was withheld for 8 hours. The enzyme was superior to a previously explored therapeutic regimen consisting of penicillin and its combination with chloramphenicol and sulfamethoxazole.Keywords
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