The Effect on the Rat Fetus of Transplacentally Acquired Tétracycline

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Abstract
These observations indicate that transplacentally acquired tetracycline deposits throughout the fetal skeleton, and its localization in growing bone is manifest by a characteristic fluorescence under UV light. The gross effect produced by the tetracycline fluorophore is a marked reduction in fetal size and weight. The critical period for this tetracycline effect on fetal growth appears to be between the 10th-12th day of gestation. Though minor skeletal anomalies have been reported in the offspring of mice treated with tetracycline, we did not observe any gross malformations in the fetuses of the tetracycline treated pregnant rats. This may represent a species difference in sensitivity to the drug. It is also noteworthy that the administration of Kanamycin to 15 pregnant rats produced no gross fetal malformations.

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