Predictable Reduction in Anticoagulant Activity of Warfarin by Small Amounts of Vitamin K
- 12 January 1975
- journal article
- clinical trial
- Published by Wiley in Acta Medica Scandinavica
- Vol. 198 (1-6) , 269-270
- https://doi.org/10.1111/j.0954-6820.1975.tb19538.x
Abstract
After withdrawal of warfarin (Marevan), 48-72 hours are required to raise the Thombotest values from a therapeutic level (range 5-10%) to 12% or higher. By i.v. administration of 1 mg vitamin K1 (Konakion) and without changing the dose of the anticoagulant, this effect could be obtained within 24 hours. Furthermore, the effect of vitamin K vanished within 2-5 days. The use of small amounts of vitamin K may therefore be a simple and reliable way of obtaining a rapid, temporary reduction in anticoagulant effect.Keywords
This publication has 3 references indexed in Scilit:
- Safe per-operative anticoagulationThorax, 1967
- A Double‐blind Trial of Long‐term Anticoagulant Treatment after Myocardial InfarctionActa Medica Scandinavica, 1967