Modeling Drug Residue Uptake by Eggs: Evidence of a Consistent Daily Pattern of Contaminant Transfer into Developing Preovulatory Yolks

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Abstract
A study was conducted to determine if the chicken ovary deposits the pesticide lindane into preovulatory egg yolks in a daily pattern similar to that previously reported for both of the antibiotics ampicillin and oxytetracycline. Our laboratory has proposed that a variety of drugs or contaminants are deposited into preovulatory yolks in a consistent manner. This possibility of a consistent pattern of drug deposition in preovulatory yolks has been used as a foundation for a model which predicts the pattern of residues contained in laid eggs. In two separate experiments, 16 hens were dosed with 3 mg of lindane per kg of body weight orally approximately 1 h after oviposition (8 hens per experiment). Twenty-four hours following dosing, hens were sacrificed and the ovaries were collected. Yolks were dissected free from the individual follicles with a blunt probe. Individual large (≥0.2 g) yellow yolks and a pool of 5 small (<0.2 g) yellow yolks were collected for determination of lindane content. Samples were ...

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