A unique pattern of lymphokine synthesis is a characteristic of certain antigen-specific suppressor T cell clones

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Abstract
We report that the lymphokines (IFN-γ) and IL-10 are co-syntheslzed by previously described CD3+ TCRαβ+, minor antigen-specific suppressor T cell clones. IFN-γ and IL-10 are known to (I) be characteristically produced by different helper T cell types, Th1 and Th2 respectively, and (II) inhibit the function of the reciprocal subset of T cells: IFN-γ Inhibits the function of Th2 and IL-10 that of Th1 cells. Although Th0 cells are also known to synthesize cytoklnes of both the Th1- and Th2-type T cells, the suppressor T cells described in this report are different from Th0 cells in that they produce (I) neither IL-2 nor IL-4 molecules and (II) stimulation via their CD3-TCR system seems independent of both IL-2 and IL-4, the typical autocrine molecules for T cell proliferation. The lymphokine profile of these suppressor T (TJ cell clones, as well as those of human antigen-specific T. cells reported earlier, suggests that co-synthesis of some Th1-llke and some Th2-like cytoklnes may be a characteristic of antigen-specific T, cells as opposed to the type of reciprocal inhibition mediated through IFN-γ or IL-10, which is antigen non-specific.

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